Max out all possible research

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

The player has broken Fontaine's mind control

The player has taken a picture of Sander Cohen's corpse

Fully research the Nitro Splicer

The player has successfully completed 50 hacks

The player has fully researched the Leadhead Splicer

Take at least one photo in every research group

The player has fully upgraded two weapons

The player has fully researched the Spider Splicer