Spend an Attribute Point

Complete 15 underwater locations.

Complete the game on Survivor difficulty without using a Vita-chamber

Complete the game on Survivor difficulty

The player has completed the game without harvesting any Little Sisters

The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade five weapons

The player has successfully invented all possible ammo types

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has taken a picture of Sander Cohen's corpse

The player has defeated Andrew Ryan