Fully research the Little Sister

The player has completed Sander Cohen's great masterpiece

Fully research the Nitro Splicer

Hit the jackpot at a slot machine

The player has successfully invented at least one item

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Houdini Splicer

The player has fully researched the Spider Splicer

The player has defeated Peach Wilkins

The player has fully researched the Leadhead Splicer

The player has taken a Research Photo of the highest grade

The player has defeated the crazed Dr. Steinman