Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

Fully research the Rosie

The player has entered Sander Cohen's personal quarters

Fully research the Nitro Splicer

The player has defeated Andrew Ryan

The player has successfully invented all possible ammo types

The player has fully upgraded two weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

Hit the jackpot at a slot machine

Fully research the Houdini Splicer

The player has fully researched the Leadhead Splicer