Complete the game on Survivor difficulty without using a Vita-chamber

Complete the game on Survivor difficulty

The player has defeated Atlas

Fully research the Little Sister

Find every audio diary

The player has either Harvested or Rescued every possible Little Sister

Fully research the Rosie

Purchased every slot in all four Plasmid and Tonic tracks

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Take at least one photo in every research group

The player has defeated Andrew Ryan