The player has successfully invented all possible ammo types

The player has completed Sander Cohen's great masterpiece

The player has fully researched the Spider Splicer

The player has purchased every slot in one of the Plasmid or Tonic tracks

Craft 10 Weapons

Kill 500 enemies on Quests

Upgrade 20 Rooms to Level 3

Build 50 rooms

Level up a dweller from Level 1 to 10

Successfully complete 50 Room Rushes

Kill 10 Quest Bosses

Build 25 rooms

Merge 3 Power Rooms