In the Main Campaign, spent $10,000 at the vending machines of Columbia.

Complete Level 15 - The Final Showdown.

In the Main Campaign, upgraded one attribute (Health, Shield, or Salts) to its maximum level.

In the Main Campaign, looted 200 containers.

In the Main Campaign, killed 20 enemies with a Sky-Hook Execution.

Unlocked all trophies

Finished the game without using Vita-Chambers.

Found or purchased all 11 basic Plasmid types.

Saved every Little Sister and spared Grace, Stanley and Gil.

Dealt with every Little Sister.

Found 100 audio diaries.

Killed an enemy with its own projectile.